Molecular cloning of the genes encoding the muscarinic acetylcholine receptors has shwon that receptor subtypes classified on the basis of pharmacological properties are related polypeptides encoded by distinct genes. These studies have laso revealed the existence of novel muscarinic receptor subtypes. Functional analysis of each of the subtypes expressed in mammalian cells indicates that the different subtypes activate distinct biochemical pathways, a finding that explains the tissue‐specific physiological response elicited by the neurotransmitter, acetylcholine.

Starting in June 2012, a series of articles in the journal Nature and in the online journals of the Public Library of Science made public the first results of a massive, international collaborative scientific endeavor known as the “Human Microbiome Project” . This project, which is attempting to categorize the vast number of microbiological species and organisms that live in and on the “healthy” human body, raises important questions about what it means to be a whole individual organism, especially if (...) that individual involves a community of some hundreds of trillions of others. In this article, we will explore a handful of political, ethical, and philosophical issues that this new research raises .. (shrink)

I wish to thank Klaus Kühnle who streamlined in [8] several of my definitions and proofs concerning the subject matter of this paper. Some ideas and results arose from discussions with Klaus Leeb. Jan Johannsen discovered some mistakes in an earlier version.

Recently a growing number of biologists have begun to consider the causal role that processes of embryonic development may play in evolution. This constitutes a reunion of these phenomena which had been linked in the nineteenth century through Haeckel's biogenetic law. This reunion may result in a new subdiscipline of biology, if there is a set of unique concepts and methods which tie the various research approaches together. Such concepts as bauplan, canalization, and developmental constraint, may serve in such a (...) capacity. The methods employed must combine comparative and experimental analyses, with special attention paid to the range of variation in developmental events within each taxon. These concepts and methods are also applicable to the problem of how development evolved, thus the evolution of development may also be considered part of the reunion. The reunion is discussed in terms of the potential participation of various schools of thought found in the current literature. (shrink)

The purpose of this brief introduction is to describe the origin of the papers here presented and to acknowledge the help of some of the many individuals who were involved in the preparation of this volume. Of the eighteen papers, nine stem from the annual fall colloquium of the Depart ment of Philosophy at the University of Western Ontario held in London, Ontario from November 10 to November 12, 1967. The colloquium was entitled 'Philosophical Logic'. After some discussion, the editors (...) decided to retain that title for this volume. Von Wright's paper 'On the Logic and Ontology of Norms' is printed here after some revision. A. R. Anderson commented on the paper at the colloquium, but his comments here are based upon the revised version of the von Wright paper. The chairman of the session at which von Wright's paper was read and discussed was T. A. Goudge. Aqvist's paper 'Scattered Topics in Interrogative Logic', and Belnap's comments, 'Aqvist's Cor rections-Accumulating Question-Sequences', are printed as delivered. The chairman of the Aqvist-Belnap session was R. E. Butts. Wilfrid Sellars' paper 'Some Problems about Belief' is printed as delivered at the col loquium, but 'Quantifiers, Beliefs, and Sellars' by Ernest Sosa is a revision of his comments at the colloquium. That session was chaired by G. D. W. Berry. Ackermann's paper 'Some Problems oflnductive Logic', as well as Skyrms' comments, are printed as delivered. (shrink)

My reason for bringing up the familiar matter of phenomenalism is both critical and historical. Almost to a man those who have been interested in arguing for or against phenomenalism have assumed that Berkeley was a phenomenalist. Now if Berkeley's doctrine is appropriately named “phenomenalism,” then it is a phenomenalism of a quite different stripe from the twentieth century variety, though many who have described his doctrine as phenomenalism have not sufficiently stressed the difference.

This presentation of the main phases and features of political thought in the sixteenth century is based on an exhaustive study of contemporary writings in Latin, English, French, German and Italian. The book is divided into four parts. The first part deals with the new thought of Protestantism. The rest describes special ideas that emerged in England, France and Italy.

Summary: This is a provocative book for those who have closely aligned themselves with a specific research or pedagogical paradigm. The underlying theme of the book is to encourage multiple approaches to educational research that will inform practice... Although the book is more about eclecticism than constructivism, it can serve as a basis for many discussions on educational research as it is and where it should go.

Biobanking of patient-derived materials is routine in health care, research, and public health emergencies. Ethical guidelines for biobanking address concerns including some about genetic materials, informed consent, confidentiality, regulatory environments, and standards of governance. This chapter identifies some limitations of existing guidelines that were apparent to one author during an Ebola outbreak, and specifies five ethical concerns about biobanking that warrant additional attention: misconceptions about biobanking, unknown consequences for donors, socioeconomic inequities that compound vulnerabilities, lasting and proportional benefits in North-South (...) research, and contextual challenges to disclosure and understanding. These affect patients, donors, health systems, research, and policy, and are amplified during public health emergencies. (shrink)

Das onto-logische Sechseck ist eine Erweiterung des (aristotelischen) onto-logischen Vierecks um singuläre und universelle Sachverhalte. Beide Vielecke inkorporieren ontische, logische und ontisch-logische Relationen. Dies ist der Grund für die Bindestrichschreibung "ontologisch". Das onto-logische Sechseck liefert die Grundlage für eine neue Definition der Wahrheit eines Satzes.